Betacellulin antibody (AA 32-111)

Catalog No. ABIN6654020

The Rabbit Polyclonal anti-Betacellulin antibody (ABIN6654020) specifically detects Betacellulin in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Betacellulin antibody (AA 32-111) (ABIN6654020)

Target: Betacellulin (BTC)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Betacellulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Betacellulin Antibody

Binding Specificity: AA 32-111

Purpose: BTC Antibody / Betacellulin

Purification: Antigen affinity purified

Immunogen: Amino acids D32-Y111 from the human protein were used as the immunogen for the BTC antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the BTC antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the BTC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Betacellulin

Target: Betacellulin (BTC)

Alternative Name: BTC

Background: Betacellulin is a protein that in humans is encoded by the BTC gene located on chromosome 4 at locus 4q13-q21. This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.

UniProt: P35070

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway