CASR antibody (AA 926-1078)

Catalog No. ABIN6654119

The Mouse Monoclonal anti-CASR antibody (Clone 11E9-) (ABIN6654119) specifically detects CASR in WB. The antibody is reactive with Human samples.

Quick Overview for CASR antibody (AA 926-1078) (ABIN6654119)

Target: CASR (Calcium-Sensing Receptor (CASR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CASR antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 11E9-

Product Details anti-CASR Antibody

Binding Specificity: AA 926-1078

Purpose: CASR Antibody / Calcium Sensing Receptor

Purification: Protein G affinity

Immunogen: Human CASR recombinant protein (amino acids Q926-S1078) was used as the immunogen for the CASR antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the CASR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CASR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CASR

Target: CASR (Calcium-Sensing Receptor (CASR))

Alternative Name: CASR

Background: The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis