Recombinant CD44 antibody

Catalog No. ABIN6654297

This Rabbit Monoclonal antibody specifically detects CD44 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant CD44 antibody (ABIN6654297)

Target: CD44

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD44 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: HCM15-2R

Product Details anti-CD44 Antibody

Purpose: Recombinant HCAM Antibody (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogen: Stimulated human leukocytes were used as the immunogen for the recombinant HCAM antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant HCAM antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant HCAM antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for CD44

Target: CD44

Alternative Name: CD44 / HCAM

Background: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9, the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). [UniProt]

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling