Recombinant GP2 antibody (AA 35-179)

Catalog No. ABIN6654854

The Rabbit Monoclonal anti-GP2 antibody (Clone GP2-2569R) (ABIN6654854) specifically detects GP2 in WB, ELISA and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant GP2 antibody (AA 35-179) (ABIN6654854)

Target: GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: GP2-2569R

Product Details anti-GP2 Antibody

Binding Specificity: AA 35-179

Purpose: Recombinant Glycoprotein 2 Antibody / GP2 / ZAP75 (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogen: A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the recombinant Glycoprotein 2 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Glycoprotein 2 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant Glycoprotein 2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for GP2

Target: GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))

Alternative Name: Glycoprotein 2

Background: GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

UniProt: P55259