p63 antibody (full length)

Catalog No. ABIN6655001

The Mouse Monoclonal anti-p63 antibody (Clone TP63-11) (ABIN6655001) specifically detects p63 in IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for p63 antibody (full length) (ABIN6655001)

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This p63 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TP63-11

Product Details anti-p63 Antibody

Binding Specificity: full length

Purpose: p63 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Full length human recombinant protein was used as the immunogen for the p63 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the p63 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the p63 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for p63

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Alternative Name: p63 / Tumor protein 63

Background: P63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands, however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90 % . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80 %. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.

UniProt: Q9H3D4