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MECP2 antibody (C-Term)

MECP2 Reactivity: Human WB, ELISA, ChIP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6655271
  • Target See all MECP2 Antibodies
    MECP2 (Methyl CpG Binding Protein 2 (MECP2))
    Binding Specificity
    • 19
    • 11
    • 8
    • 8
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 101
    • 40
    • 31
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Human
    Host
    • 100
    • 7
    • 1
    Rabbit
    Clonality
    • 101
    • 7
    Polyclonal
    Conjugate
    • 62
    • 10
    • 8
    • 8
    • 7
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MECP2 antibody is un-conjugated
    Application
    • 79
    • 63
    • 36
    • 30
    • 12
    • 10
    • 8
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Chromatin Immunoprecipitation (ChIP)
    Purification
    Anti-MeCP2 Antibody was purified by affinity purification. This product reacts with human MeCP2.  Cross reactivity with MeCP2 from species other than human is not known.
    Immunogen

    Immunogen: Anti-MeCP2 Antibody was produced in rabbits by repeated immunizations with a synthetic peptide containing the C-terminal region of human MeCP2.

    Immunogen Type: Peptide

    Isotype
    IgG
    Top Product
    Discover our top product MECP2 Primary Antibody
  • Application Notes

    Application Note: Anti-MeCP2 Antibody is suitable for Chromatin Immunoprecipitation, ELISA and Western Blots. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 70 kDa in the appropriate cell lysate or extract.

    ChIP Dilution: 5 μg per IP

    ELISA Dilution: 1:1,000

    Western Blot Dilution: 1:1,000

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer

    Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2

    0.05 % (w/v) Sodium Azide and 0.05 % ProClin 300/p>

    Stabilizer: None

    Preservative
    ProClin, Sodium azide
    Precaution of Use
    This product contains Sodium azide and ProClin: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Storage
    RT,4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
  • Target
    MECP2 (Methyl CpG Binding Protein 2 (MECP2))
    Alternative Name
    MeCP2 (MECP2 Products)
    Synonyms
    AUTSX3 antibody, MRX16 antibody, MRX79 antibody, MRXS13 antibody, MRXSL antibody, PPMX antibody, RS antibody, RTS antibody, RTT antibody, 1500041B07Rik antibody, BB130002 antibody, D630021H01Rik antibody, Mbd5 antibody, WBP10 antibody, wu:fk96a04 antibody, zgc:111857 antibody, methyl-CpG binding protein 2 antibody, methyl CpG binding protein 2 antibody, methyl-CpG binding protein 2 S homeolog antibody, MECP2 antibody, Mecp2 antibody, mecp2 antibody, mecp2.S antibody
    Background

    Synonyms: Methyl-CpG-binding protein 2, MeCP-2 protein, AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RTS, RTT

    Background: MeCP2 is a chromosomal protein with abundant binding sites in the chromatin. It belongs to the family of methyl CpG binding proteins which also comprises MBD1, MBD2, MBD3 and MBD4. MeCP2 can bind specifically to methylated promoters, thereby repressing transcription. This transcriptional repression is mediated through interaction with histone deacetylase and the corepressor SIN3A. MeCP2 also is essential for development. Mutations in MeCP2 are the cause of several types of mental retardation including Rett syndrome, a progressive neurological disorder that causes mental retardation in females and mental retardation syndromic X-linked type 13, and may also be involved in Angelman syndrome and susceptibility to some types of autism. Anti-MeCP2 Antibody is ideal for research in Epigenetics, Embryonic Development and Neuroscience.

    Gene Name: MECP2

    Gene ID
    4204
    NCBI Accession
    NP_001104262
    UniProt
    P51608
    Pathways
    Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane
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