KDM5C antibody

Catalog No. ABIN7861649

This Mouse Monoclonal antibody specifically detects KDM5C in FACS. It exhibits reactivity toward Human.

Quick Overview for KDM5C antibody (ABIN7861649)

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KDM5C antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: PCRP-KDM5C-1A11

Product Details anti-KDM5C Antibody

Purpose: KDM5C Antibody

Specificity: SmcX, also known as JARID1C (jumonji, AT rich interactive domain 1C), MRXJ, KDM5C or XE169, is a nuclear protein that contains one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers and belongs to the JARID1 histone demethylase family. Expressed ubiquitously with highest expression in brain and skeletal muscle, SmcX functions as a histone demethylase that removes methyl groups from lysine residues on Histone H3, thereby playing a role in the histone code, as well as transcriptional regulation and chromatin remodeling. SmcX binds iron and a-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements, thus repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are associated with X-linked mental retardation (XLMR), a condition characterized by cognitive impairment and a low IQ. Multiple isoforms of SmcX are expressed due to alternative splicing events.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human KDM5C protein

Isotype: IgG2c

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for KDM5C

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Alternative Name: KDM5C

Background:

DXS1272E, JARID1C, MRX13, SMCX, XE169

HeLa cells.

Molecular Weight: 176kDa

Gene ID: 8242, 631768

UniProt: P41229

Pathways: Warburg Effect