Lamin A/C antibody

Catalog No. ABIN6656055

Supplier Product No.: 200-301-x12

This Mouse Monoclonal antibody specifically detects Lamin A/C in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for Lamin A/C antibody (ABIN6656055)

Target: Lamin A/C (LMNA)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 4C4

Product Details anti-Lamin A/C Antibody

Supplier Product No.: 200-301-x12

Supplier: Rockland

Purpose: Lamin A/C Antibody

Purification: Anti-Lamin A/C Antibody was purified from tissue culture supernatant by protein G chromatography.

Sterility: Sterile filtered

Immunogen: Anti-Lamin A/C Antibody was produced in mice by repeated immunizations with a recombinant full length human lamin C expressed in and purified from E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA_Dilution: 1:50,000

Immunohistochemistry_Dilution: 1:1000

Western_Blot_Dilution: 1:5000

Other: ICC: 1:1000

Comment:

Anti-Lamin A/C Antibody is tested for Western Blot, Immunocytochemistry, and Immunohistochemistry, and it is specific for the ~64 and 74 kDa lamin A and C proteins. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.

Expiry Date: 12 months

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: Lamin A/C

Background:

Synonyms: Prelamin-A/C, 70 kDa lamin, Renal carcinoma antigen NY-REN-32, LMN1

Background: Lamins A and C are nuclear structural proteins that are part of the intermediate filament family and coded for by the same gene (LMNA). Lamins A and C are nearly identical except for their carboxy termini. Mutations in the gene encoding lamins A/C have been shown to cause a variety of diseases including autosomal dominant Emery-Dreifuss muscular dystrophy, autosomal dominant limb-girdle muscular dystrophy and Charcot-Marie-Tooth disorder type 2. Lamin A/C Antibody is ideal for researchers interested in cancer research.

Gene Name: LMNA

Gene ID: 4000

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus