GPBAR1 antibody (C-Term)

Catalog No. ABIN6657009

Supplier Product No.: 100-401-h59

This Rabbit Polyclonal antibody specifically detects GPBAR1 in WB. It exhibits reactivity toward Human.

Quick Overview for GPBAR1 antibody (C-Term) (ABIN6657009)

Target: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPBAR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GPBAR1 Antibody

Binding Specificity: C-Term

Supplier Product No.: 100-401-h59

Supplier: Rockland

Purpose: BG37 Antibody

Cross-Reactivity (Details): A BLAST analysis was used to suggest cross-reactivity with BG37 from human and mouse based on 100 % homology with the immunizing sequence.

Purification: Anti-BG37 Antibody is sera.

Immunogen: BG37 Antibody was produced from whole rabbit serum which was prepared by repeated immunizations with the amino acid portion of human BG37 near the C-terminus of the chain .

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000-1:5000

Comment:

Anti-BG37 Antibody has been tested in WB. Expect a band approximately 37kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Optional[Buffer]: 50 % (v/v) Glycerol ,0.05 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for GPBAR1

Target: GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Alternative Name: BG37

Background:

Synonyms: TGR5, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, hGPCR19, Membrane-type receptor for bile acids, M-BAR, hBG37, BG37

Background: Anti-BG37 TGR5 Antibody detects human BG37tgr5. BG37 is a 330 amino acid novel enzyme with seven transmembrane domains. It belongs to the G protein-coupled receptor (GPCR) superfamily and functions as a cell surface receptor for bile acids. Cells expressing BG37 when treated with bile acids induce the production of intracellular cAMP, activate the MAP kinase signaling pathway, leads to the internalization of the receptor and regulates proglucagon gene expression in enteroendocrine cells. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids that can be targeted to improve metabolic control. It is known to be ubiquitously expressed in most of the tissues. Anti-BG37 TGR5 Antibody is ideal for investigators involved in kinase, phosphatase, and NFkappaB research.

Gene Name: GPBAR1

Gene ID: 151306

NCBI Accession: NP_001070659

UniProt: Q8TDU6

Pathways: WNT Signaling, Hormone Transport, Sensory Perception of Sound