GRIN2B antibody (C-Term)

Catalog No. ABIN6657529

Supplier Product No.: 600-401-p64

The Rabbit Polyclonal anti-GRIN2B antibody has been validated for WB. It is suitable to detect GRIN2B in samples from Human.

Quick Overview for GRIN2B antibody (C-Term) (ABIN6657529)

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIN2B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GRIN2B Antibody

Binding Specificity: C-Term

Supplier Product No.: 600-401-p64

Supplier: Rockland

Purpose: NMDAR2B Antibody

Cross-Reactivity (Details): Anti-NMDAR2B antibody is directed against human NMDAR2B protein.

Purification: The product was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: NMDAR2B affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a sequence at the C-terminal of human NMDAR2B.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 0.5 μg/mL

Comment:

Anti-NMDAR2B is tested for Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~166.4 kDa corresponding to the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution:

Reconstitution_Buffer: Restore with deionized water (or equivalent)

Reconstitution_Volume: 100 μL

Buffer:

Buffer: 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide

Stabilizer: 5 mg BSA

Preservative: 0.05 mg Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at 4° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for GRIN2B

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Alternative Name: NMDAR2B

Background:

Synonyms: Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,

Background: The N-methyl-D-aspartate receptor 2B, also names as GRIN2B. The sequence of the predicted 1,484-amino acid human protein is 98 % and 96 % identical to the sequences of the rat and mouse Nmdar2b proteins, respectively. Nmdar2B gene is located on mouse chromosome 6 between Rho and Ly49 centromerically and Glb telomerically. Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12 overexpression of NMDA receptor 2B (NR2B) in the forebrains of transgenic mice leads to enhanced activation of NMDA receptors, facilitating synaptic potentiation in response to stimulation at 10-100 Hz. This antibody is suitable for researchers interested in neuroscience research.

Gene Name: GRIN2B

Gene ID: 2904

NCBI Accession: NP_000825

UniProt: Q13224

Pathways: Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity