NMDAR2A antibody (C-Term)

Catalog No. ABIN6658128

Supplier Product No.: 100-401-c86

This Rabbit Polyclonal antibody specifically detects NMDAR2A in WB. It exhibits reactivity toward Rat.

Quick Overview for NMDAR2A antibody (C-Term) (ABIN6658128)

Target: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NMDAR2A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NMDAR2A Antibody

Binding Specificity: C-Term

Supplier Product No.: 100-401-c86

Supplier: Rockland

Purpose: NMDA R2A Antibody

Cross-Reactivity (Details): Anti-NMDA R2A antibody is directed against NMDA R2A protein.

Purification: The antibody was prepared from monospecific neat serum.

Immunogen: Anti-NMDA R2A Antibody was produced by repeated immunizations with fusion protein from the C-terminal region of the NR2A subunit

Isotype: IgG

Application Details

Application Notes:

Western_Blot_Dilution: 1:1000

Other: User Optimized

Comment:

Anti-NMDA R2A Antibody has been tested by Western Blotting. Expect a band of approximately 180kDa in size corresponding to the NR2A subunit of the NMDA receptor in appropriate cell lysate or extract. A dilution of 1:1000 is recommended although specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for NMDAR2A

Target: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Alternative Name: NMDA R2A

Background:

Synonyms: Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDAR2A, NR2A, Grin2a

Background: NMDA R2A Antibody detects NMDA R2A protein. The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Anti-NMDA R2A Antibody is ideal for investigators involved in Neuroscience, Cell Signaling, and Signal Transduction research.

Gene Name: GRIN2A

Gene ID: 24409

UniProt: Q00959

Pathways: Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity