GRIN2B antibody (C-Term)

Catalog No. ABIN6658130

Supplier Product No.: 100-401-c87

This anti-GRIN2B antibody is a Rabbit Polyclonal antibody detecting GRIN2B in WB. Suitable for Rat.

Quick Overview for GRIN2B antibody (C-Term) (ABIN6658130)

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIN2B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GRIN2B Antibody

Binding Specificity: C-Term

Supplier Product No.: 100-401-c87

Supplier: Rockland

Purpose: NMDA R2B Antibody

Cross-Reactivity (Details): Anti-NMDA R2B antibody is directed against NMDA R2Bprotein.

Purification: The antibody was prepared from monospecific neat serum.

Immunogen: Anti-NMDA R2B Antibody was produced by repeated immunizations with a fusion protein from the C-terminal region of the NR2B subunit.

Isotype: IgG

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:1000

Comment:

Anti-NMDA R2B Antibody has been tested in Western Blotting. Expect a band of approximately 180kDa in size corresponding to the NR2B subunit of the NMDA receptor in appropriate cell lysate or extract. A dilution of 1:1000 is recommended in western blotting although specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for GRIN2B

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Alternative Name: NMDA R2B

Background:

Synonyms: Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, Grin2b

Background: NMDA R2B Antibody detects NMDA R2B protein. The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Anti-NMDA R2B Antibody is ideal for investigators involved in Neuroscience, Signal Transduction, and Cell Signaling Research.

Gene Name: GRIN2B

Gene ID: 24410

UniProt: Q00960

Pathways: Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity