SLC6A1 antibody (C-Term)

Catalog No. ABIN6658161

Supplier Product No.: 612-401-d56

This Rabbit Polyclonal antibody specifically detects SLC6A1 in WB and IHC. It exhibits reactivity toward Rat.

Quick Overview for SLC6A1 antibody (C-Term) (ABIN6658161)

Target: SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC6A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SLC6A1 Antibody

Binding Specificity: C-Term

Supplier Product No.: 612-401-d56

Supplier: Rockland

Purpose: GABA Transporter 1 (GAT1) Antibody

Cross-Reactivity (Details): Anti-GABA Transporter 1 antibody is directed against rat GABA Transporter 1.

Purification: GABA Transporter 1 antibodies are affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-GABA Transporter 1 Antibody was produced in rabbit by repeated immunizations with synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.

Isotype: IgG

Application Details

Application Notes:

Immunohistochemistry_Dilution: 1:100-200

Western_Blot_Dilution: 1:1000

Comment:

Anti-GAT1 (Rabbit) Antibody is tested for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 67 kDa in size corresponding to GABA Transporter 1 protein in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for SLC6A1

Target: SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))

Background:

Synonyms: Sodium- and chloride-dependent GABA transporter 1, Solute carrier family 6 member 1

Background: Gamma-aminobutyric acid (GABA) Antibody detects GABA which is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia. GAT-1 is thought to play a key role in epileptogenesis. Anti-GAT1 Antibody is ideal for investigators involved in Neuroscience.

Gene Name: SLC6A1

Gene ID: 79212

UniProt: P23978