TXN antibody (AA 51-105)

Catalog No. ABIN668871

This anti-TXN antibody is a Rabbit Polyclonal antibody detecting TXN in WB, ELISA, IHC (p), IHC (fro), IF (cc) and IF (p). Suitable for Human, Rat and Mouse. This Primary Antibody has been cited in 3+ publications.

Quick Overview for TXN antibody (AA 51-105) (ABIN668871)

Target: TXN (Thioredoxin (TXN))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXN antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-TXN Antibody

Binding Specificity: AA 51-105

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Thioredoxin

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-TXN antibody (ABIN668871)

Zhang, Hu, Guo, Wang, Zhao, Zhang, Yang, Yu, Niu, Yang, Zheng, Wang: "Screening and identification of post-traumatic stress-related serum factors in children with Wilms' tumors." in: Oncology letters, Vol. 11, Issue 2, pp. 1299-1304, (2016) (PubMed).

Gao, Yuan, Gao, Cai, Zhu, Liu, Wang, Wei, Huang, Liang, Gao: "Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles." in: Biomaterials, Vol. 35, Issue 31, pp. 8854-66, (2014) (PubMed).

Li, Sun, Xiao, Sun: "First characterization of a teleost Epstein-Barr virus-induced gene 3 (EBI3) reveals a regulatory effect of EBI3 on the innate immune response of peripheral blood leukocytes." in: Developmental and comparative immunology, Vol. 41, Issue 4, pp. 514-22, (2013) (PubMed).

Target Details for TXN

Target: TXN (Thioredoxin (TXN))

Alternative Name: Thioredoxin

Background:

Synonyms: TRX, TRDX, TRX1, Thioredoxin, ATL-derived factor, ADF, Surface-associated sulphydryl protein, SASP, TXN

Background: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).

Gene ID: 7295

UniProt: P10599

Pathways: Carbohydrate Homeostasis, Cell RedoxHomeostasis