PTGS2 antibody (AA 501-604)

Catalog No. ABIN672471

Cited in 14+ publications. The Rabbit Polyclonal anti-PTGS2 antibody (ABIN672471) specifically detects PTGS2 in WB, ELISA, IHC (p), IF (cc), IF (p), FACS and IHC (fro). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PTGS2 antibody (AA 501-604) (ABIN672471)

Target: PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTGS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-PTGS2 Antibody

Binding Specificity: AA 501-604

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse Cyclooxygenase 2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-PTGS2 antibody (ABIN672471)

Kellermann, Janssen, Münch, Koch, Schneider-Stock, Cesnjevar, Rüffer: "Deep hypothermic circulatory arrest or tepid regional cerebral perfusion: impact on haemodynamics and myocardial integrity in a randomized experimental trial." in: Interactive cardiovascular and thoracic surgery, Vol. 26, Issue 4, pp. 667-672, (2018) (PubMed).

Chen, Hou, Fan, Jin, Wang: "Sonic hedgehog protein regulates fibroblast growth factor 8 expression in metanephric explant culture from BALB/c mice: Possible mechanisms associated with renal morphogenesis." in: Molecular medicine reports, Vol. 14, Issue 4, pp. 2929-36, (2017) (PubMed).

Hu, Xi, Cao, Yang, Liu, Sheng, Han, Yuan, Guo, Weng, Xu: "The expression of prostaglandin-E2 and its receptor in the oviduct of Chinese brown frog (Rana dybowskii)." in: Prostaglandins & other lipid mediators, Vol. 124, pp. 9-15, (2016) (PubMed).

Li, Xu, Jiang, Bi, Xu, Han: "Lipopolysaccharide induces inflammation and facilitates lung metastasis in a breast cancer model via the prostaglandin E2-EP2 pathway." in: Molecular medicine reports, Vol. 11, Issue 6, pp. 4454-62, (2015) (PubMed).

Liu, Duan, Chang, Zhang, Chu, Li, Dai, Mo, Chang: "Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression." in: PLoS ONE, Vol. 9, Issue 6, pp. e98560, (2015) (PubMed).

Wallace, Zheng, Kanazawa, Shih: "Immunopathology of inflammatory bowel disease." in: World journal of gastroenterology : WJG, Vol. 20, Issue 1, pp. 6-21, (2014) (PubMed).

Li, Li, Mu, Zhang, Yao, Li, Niu: "Protective effect of sanguinarine on LPS-induced endotoxic shock in mice and its effect on LPS-induced COX-2 expression and COX-2 associated PGE2 release from peritoneal macrophages." in: International immunopharmacology, Vol. 22, Issue 2, pp. 311-7, (2014) (PubMed).

Zhang, Wu, Wan, Song, Xu, Xu, Chang, Tai, Dong, Liu: "Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats." in: World journal of gastroenterology : WJG, Vol. 20, Issue 6, pp. 1614-22, (2014) (PubMed).

de Moraes, Maia, de Lima, Dias, Raposo-Ferreira, Sudano, Junior, Oba et al.: "Temporal analysis of prostaglandin F2? receptor, caspase 3, and cyclooxygenase 2 messenger RNA expression and prostaglandin F2? receptor and cyclooxygenase 2 protein expression in endometrial tissue ..." in: Theriogenology, Vol. 83, Issue 2, pp. 276-84, (2014) (PubMed).

Gao, Wen, Yang, Lu, Tong, Huang, Liu, Tang: "Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis." in: PLoS ONE, Vol. 8, Issue 7, pp. e69309, (2013) (PubMed).

Chu, He, Kuang, Ren, Gou: "Celastrol protects kidney against ischemia-reperfusion-induced injury in rats." in: The Journal of surgical research, Vol. 186, Issue 1, pp. 398-407, (2013) (PubMed).

Li, Wang, Jiang, Xu, Zhang, Liu, Zhai: "Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo." in: International journal of molecular sciences, Vol. 12, Issue 1, pp. 668-81, (2011) (PubMed).

Li, Jiang, Xu, Wang, Zhang, Liu, Zhai: "Cyclin D1 expression and the inhibitory effect of celecoxib on ovarian tumor growth in vivo." in: International journal of molecular sciences, Vol. 11, Issue 10, pp. 3999-4013, (2010) (PubMed).

Target Details for PTGS2

Target: PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))

Alternative Name: Cyclooxygenase 2

Background:

Synonyms: COX2, Cox-2, PHS-2, Pghs2, TIS1, PGHS-2, Prostaglandin G/H synthase 2, Cyclooxygenase-2, Glucocorticoid-regulated inflammatory cyclooxygenase, Gripghs, Macrophage activation-associated marker protein P71/73, PES-2, PHS II, Prostaglandin H2 synthase 2, PGH synthase 2, Prostaglandin-endoperoxide synthase 2, TIS1 protein, Ptgs2, Pghs-b

Background: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Gene ID: 19225

UniProt: Q05769

Pathways: Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation