Presenilin 1 antibody (AA 107-156)

Catalog No. ABIN6748598

This Rabbit Polyclonal antibody specifically detects Presenilin 1 in WB, IHC and IHC (p). It exhibits reactivity toward Human, Mouse, Rat, Monkey, Pig, Guinea Pig, Dog, Bat and Hamster.

Quick Overview for Presenilin 1 antibody (AA 107-156) (ABIN6748598)

Target: Presenilin 1 (PSEN1)

Reactivity: Human, Mouse, Rat, Monkey, Pig, Guinea Pig, Dog, Bat, Hamster

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Presenilin 1 Antibody

Binding Specificity: AA 107-156

Brand: IHC-plus™

Specificity: Human PSEN1 / Presenilin 1

Predicted Reactivity: Percent identity by BLAST analysis: Human, Mouse, Pig, Guinea pig (100%) Bovine, Zebrafish (92%).

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide located between aa107-156 of human PSEN1 (P49768, NP_000012). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Dog, Bat, Pig, Opossum, Guinea pig, Lizard (100%), Bovine, Xenopus, Zebrafish (92%), Galago, Rabbit, Horse, Platypus, Salmon (85%).

Type of Immunogen: Synthetic peptide

Application Details

Application Notes: Approved: IHC, IHC-P (5 μg/mL), WB (0.2 - 1 μg/mL)

Usage: Western Blot: Suggested dilution at 1 μg/mL in 5 % skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS with 2 % sucrose

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year)
Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.

Target Details for Presenilin 1

Target: Presenilin 1 (PSEN1)

Alternative Name: PSEN1 / Presenilin 1

Background: Name/Gene ID: PSEN1
Subfamily: Aspartic A22A
Family: protease

Synonyms: PSEN1, AD3, Alzheimer disease 3, FAD, Protein S182, PS1, S182, PS-1, PSNL1, Presenilin 1, Presenilin-1

Gene ID: 5663

NCBI Accession: NP_000012

UniProt: P49768

Pathways: Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport