Presenilin 1 antibody (AA 300-349)

Catalog No. ABIN6748645

The Rabbit Polyclonal anti-Presenilin 1 antibody has been validated for WB, IHC and IHC (p). It is suitable to detect Presenilin 1 in samples from Human, Mouse, Monkey, Cow, Pig, Guinea Pig and Horse.

Quick Overview for Presenilin 1 antibody (AA 300-349) (ABIN6748645)

Target: Presenilin 1 (PSEN1)

Reactivity: Human, Mouse, Monkey, Cow, Pig, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Presenilin 1 Antibody

Binding Specificity: AA 300-349

Brand: IHC-plus™

Specificity: Human PSEN1 / Presenilin 1

Predicted Reactivity: Percent identity by BLAST analysis: Human, Guinea pig (100%) Mouse, Bovine, Horse, Pig (85%).

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide located between aa300-349 of human PSEN1 (P49768, NP_000012). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Guinea pig (100%), Opossum (92%), Mouse, Hamster, Elephant, Dog, Bovine, Bat, Horse, Pig (85%), Rat (84%).

Type of Immunogen: Synthetic peptide

Application Details

Application Notes: Approved: IHC, IHC-P (5 μg/mL), WB (0.2 - 1 μg/mL)

Usage: Western Blot: Suggested dilution at 1 μg/mL in 5 % skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50,000 - 100,000 as secondary antibody.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Distilled water

Concentration: Lot specific

Buffer: Lyophilized from PBS with 2 % sucrose

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year)
Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.

Target Details for Presenilin 1

Target: Presenilin 1 (PSEN1)

Alternative Name: PSEN1 / Presenilin 1

Background: Name/Gene ID: PSEN1
Subfamily: Aspartic A22A
Family: protease

Synonyms: PSEN1, AD3, Alzheimer disease 3, FAD, Protein S182, PS1, S182, PS-1, PSNL1, Presenilin 1, Presenilin-1

Gene ID: 5663

NCBI Accession: NP_000012

UniProt: P49768

Pathways: Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport