ARHGAP17 antibody (AA 451-550)

Catalog No. ABIN679343

The Rabbit Polyclonal anti-ARHGAP17 antibody has been validated for ELISA, IHC (p), IF (cc), IF (p) and IHC (fro). It is suitable to detect ARHGAP17 in samples from Rat.

Quick Overview for ARHGAP17 antibody (AA 451-550) (ABIN679343)

Target: ARHGAP17 (rho GTPase Activating Protein 17 (ARHGAP17))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGAP17 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ARHGAP17 Antibody

Binding Specificity: AA 451-550

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Drosophila

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from fruit fly ARHGAP17/Nadrin

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ARHGAP17

Target: ARHGAP17 (rho GTPase Activating Protein 17 (ARHGAP17))

Alternative Name: ARHGAP17

Background:

Synonyms: ARHGAP17, NADRIN, Neuron associated developmentally regulated protein, Rho GTPase activating protein 17, RhoGAP interacting with CIP4 homologs protein 1, RICH 1, RICH1, WBP15, MST066, MST110, MSTP038, PP367, PP4534, Rho type GTPase activating protein 17, RhoGAP interacting with CIP4 homologs 1, RICH1B.

Background: ARHGAP17 is a Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. It specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. RHGAP17 participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.

Gene ID: 55114