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APP antibody (Thr668, Thr743)

This anti-APP antibody is a Rabbit Polyclonal antibody detecting APP in WB, ELISA and IHC. Suitable for Human, Mouse, Rat, Dog, Cow, Rabbit, Horse, Guinea Pig, Chicken, Monkey, Pig, Zebrafish (Danio rerio) and Xenopus laevis.
Catalog No. ABIN6796338

Quick Overview for APP antibody (Thr668, Thr743) (ABIN6796338)

Target

See all APP Antibodies
APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivity

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Human, Mouse, Rat, Dog, Cow, Rabbit, Horse, Guinea Pig, Chicken, Monkey, Pig, Zebrafish (Danio rerio), Xenopus laevis

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This APP antibody is un-conjugated

Application

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • Binding Specificity

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    Thr668, Thr743

    Specificity

    Recognizes human APP when phosphorylated at Thr743/668. Species cross-Reactivity: mouse.

    Purification

    Immunoaffinity purified

    Immunogen

    Synthetic phosphopeptide corresponding to human beta Amyloid A4 around the phosphorylation site of threonine 743 (A-V-TP-P-E).

    Type of Immunogen: Synthetic phospho-peptide

    Isotype

    IgG
  • Application Notes

    Approved: ELISA (1:4000), IHC (1:50 - 1:100), WB (1:500 - 1:1000)

    Usage: Suitable for use in ELISA, Western Blot and Immunohistochemistry. ELISA:1:4000. Western Blot:1:500-1:1000. Immunohistochemistry:1:50-1:100.

    Comment

    Target Species of Antibody: Human

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    Lot specific

    Buffer

    PBS (without Mg2+, Ca2+),  pH 7.4, 150 mM sodium chloride, 0.02 % sodium azide, 50 % glycerol

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Aliquot to Avoid repeated freezing and thawing.

    Storage

    4 °C,-20 °C

    Storage Comment

    May be stored at 4°C for short-term only. Aliquot to avoid freeze-thaw cycles. Store at -20°C. Aliquots are stable for at least 1 year.
  • Target

    APP (Amyloid beta (A4) Precursor Protein (APP))

    Alternative Name

    APP / beta Amyloid

    Background

    Name/Gene ID: APP
    Family: Amyloid precursor protein

    Synonyms: APP, ABPP, A4, ABETA, AD1, Alzheimer disease, Amyloid beta, Beta-amyloid peptide, APPI, Beta amyloid, CVAP, AAA, PN2, PreA4, Amyloid beta A4 protein, Peptidase nexin-II, CTFgamma, PN-II, Protease nexin-II

    Gene ID

    351

    UniProt

    P05067

    Pathways

    Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
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