MAP1LC3A/B antibody (AA 21-121) (Biotin)

Catalog No. ABIN681585

This anti-MAP1LC3A/B antibody is a Rabbit Polyclonal antibody detecting MAP1LC3A/B in WB, IHC (p), ELISA and IHC (fro). Suitable for Human, Rat, Mouse and Rabbit.

Quick Overview for MAP1LC3A/B antibody (AA 21-121) (Biotin) (ABIN681585)

Target: MAP1LC3A/B (MAP1LC3A,B)

Reactivity: Human, Rat, Mouse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP1LC3A/B antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-MAP1LC3A/B Antibody (Biotin)

Binding Specificity: AA 21-121

Cross-Reactivity: Human, Mouse, Rabbit, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MAP1A/MAP1B LC3 B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for MAP1LC3A/B

Target: MAP1LC3A/B (MAP1LC3A,B)

Alternative Name: MAP1A/MAP1B LC3 A/B

Background:

Synonyms: MAP LC3 beta, LC3, Autophagy related protein LC3 A, Autophagy related protein LC3 B, Autophagy related ubiquitin like modier LC3 A, Autophagy related ubiquitin like modier LC3 B, MAP1 light chain 3 like protein 1, MAP1 light chain 3 like protein 2, MAP1A/1B light chain 3 A, MAP1A/1B light chain 3 B, MAP1A/1BLC3, MAP1A/MAP1B LC3 A, MAP1A/MAP1B LC3 B, MAP1ALC3, MAP1BLC3, MAP1LC3A, MAP1LC3B, Microtubule associated protein 1 light chain 3 alpha, Microtubule associated protein 1 light chain 3 beta, Microtubule associated proteins 1A/1B light chain 3, Microtubule associated proteins 1A/1B light chain 3A, Microtubule associated proteins 1A/1B light chain 3B.microtubule-associated proteins 1A/1B light chain 3 beta 2

Background: A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy.

Gene ID: 81631, 84557