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CSF1R antibody (pTyr923)

This Rabbit Polyclonal antibody specifically detects CSF1R in WB, ELISA and FACS. It exhibits reactivity toward Human, Mouse and Rat.
Catalog No. ABIN683818

Quick Overview for CSF1R antibody (pTyr923) (ABIN683818)

Target

See all CSF1R Antibodies
CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Reactivity

  • 195
  • 107
  • 75
  • 17
  • 8
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Mouse, Rat

Host

  • 209
  • 21
  • 19
  • 3
  • 3
  • 2
Rabbit

Clonality

  • 206
  • 48
  • 2
Polyclonal

Conjugate

  • 107
  • 30
  • 13
  • 11
  • 10
  • 8
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 1
  • 1
  • 1
This CSF1R antibody is un-conjugated

Application

  • 160
  • 95
  • 91
  • 72
  • 39
  • 26
  • 25
  • 22
  • 21
  • 15
  • 7
  • 5
  • 5
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Flow Cytometry (FACS)
  • Binding Specificity

    • 20
    • 16
    • 15
    • 15
    • 14
    • 12
    • 11
    • 10
    • 9
    • 8
    • 7
    • 6
    • 4
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    • 4
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    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr923

    Cross-Reactivity

    Human, Mouse, Rat

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human CSF1R around the phosphorylation site of tyrosine 923

    Isotype

    IgG
  • Application Notes

    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Expiry Date

    12 months
  • Target

    CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

    Alternative Name

    CSF1R

    Background

    Synonyms: FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R, Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor, CSF-1-R, Proto-oncogene c-Fms, CSF1R

    Background: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1.

    Gene ID

    1436

    UniProt

    P07333

    Pathways

    RTK Signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
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