COPS5 antibody (AA 221-334)

Catalog No. ABIN685912

This Rabbit Polyclonal antibody specifically detects COPS5 in WB, IHC (p), IF (cc), IF (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for COPS5 antibody (AA 221-334) (ABIN685912)

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-COPS5 Antibody

Binding Specificity: AA 221-334

Purpose: Jab1/COPS5 Polyclonal Antibody

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Jab1

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for COPS5

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Alternative Name: Jab1

Background:

Synonyms: 38 kDa Mov34 homolog, COP9 constitutive photomorphogenic homolog subunit 5, COP9 constitutive photomorphogenic homolog subunit 5, COP9 signalosome complex subunit 5, COP9 signalosome subunit 5, Cop9 subunit 5, COPS 5, COPS5, CSN 5, CSN5, JAB 1, Jun activation domain binding protein 1, Jun activation domain-binding protein, MGC3149, MOV 34, MOV34, SGN 5, SGN5, Signalosome subunit 5, CSN5_HUMAN.

Background: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.

Gene ID: 10987

Pathways: Cell Division Cycle