IL23R antibody (AA 401-550)

Catalog No. ABIN686857

This Rabbit Polyclonal antibody specifically detects IL23R in WB, IHC (p), IF (cc), IF (p) and IHC (fro). It exhibits reactivity toward Human.It has been mentioned in 1 publication

Quick Overview for IL23R antibody (AA 401-550) (ABIN686857)

Target: IL23R (Interleukin 23 Receptor (IL23R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL23R antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-IL23R Antibody

Binding Specificity: AA 401-550

Purpose: IL-23R Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL-23R

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-IL23R antibody (ABIN686857)

Wang, Zhong, Zheng, Li, Chen, Ma, Sun, Yan, Li: "Damage effect of interleukin (IL)-23 on oxygen-glucose-deprived cells of the neurovascular unit via IL-23 receptor." in: Neuroscience, Vol. 289C, pp. 406-416, (2015) (PubMed).

Target Details for IL23R

Target: IL23R (Interleukin 23 Receptor (IL23R))

Alternative Name: IL-23R

Background:

Synonyms: Interleukin-23 receptor, IL-23 receptor, IL-23R, IL23R

Background: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Gene ID: 149233

UniProt: Q5VWK5

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation