APCS antibody (AA 143-223)

Catalog No. ABIN6936424

The Mouse Monoclonal anti-APCS antibody (Clone APCS-3240) (ABIN6936424) specifically detects APCS in IHC. The antibody is reactive with Human samples.

Quick Overview for APCS antibody (AA 143-223) (ABIN6936424)

Target: APCS (Amyloid P Component, Serum (APCS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APCS antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: APCS-3240

Product Details anti-APCS Antibody

Binding Specificity: AA 143-223

Purpose: Serum Amyloid P / APCS Antibody

Specificity: Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins, which has a characteristic pentameric organization and calciumdependent ligand binding. Secreted by liver epithelial cells, SAP is found in serum and urine. Although the function of SAP has not been clearly established, it has been shown to interact with DNA and histones and is thought to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2, SAP is a precursor of the protein amyloid P component (AP), which is universally associated with the amyloid deposits in all forms of amyloidoses, including Alzheimer s disease. SAP is a decamer of ten identical, noncovalently linked subunits, each of which may be post-translationally modified by glycosylation.

Cross-Reactivity (Details): Human.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human APCS protein (around aa 143-223) (exact sequence is proprietary)

Isotype: IgG2b, kappa

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Human endometrial carcinoma tissue (IHC).

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for APCS

Target: APCS (Amyloid P Component, Serum (APCS))

Alternative Name: APCS

Background:

9.5S alpha 1 glycoprotein, Amyloid P component serum (APCS), Pentaxin related, Pentraxin 2 (PTX2), Serum Amyloid P (SAP), Serum amyloid P component

Human endometrial carcinoma tissue (IHC).

Molecular Weight: 200kDa (oligomeric), 26kDa (non-covalently bound subunit), 30kDa (glycosylated SAP subunit)

Gene ID: 325, 507080

UniProt: P02743