CD207 antibody (AA 74-213)
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- Target See all CD207 Antibodies
- CD207 (CD207 Molecule, Langerin (CD207))
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Binding Specificity
- AA 74-213
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD207 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Coating (Coat)
- Specificity
- Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment (around aa74-213) of human Langerin protein (exact sequence is proprietary)
- Clone
- LGRN-1821
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product CD207 Primary Antibody
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- Application Notes
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Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: HeLa or A549 cells (WB).
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- CD207 (CD207 Molecule, Langerin (CD207))
- Alternative Name
- CD207 (CD207 Products)
- Synonyms
- CD207 antibody, CLEC4K antibody, RGD1565913 antibody, CD207 molecule antibody, CD207 antigen antibody, CD207 antibody, Cd207 antibody
- Background
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C-type lectin domain family 4 member K, CD207, CLEC4K, Langerhans cell specific c type lectin, Langerin,Langerin / CD207 (Marker of Langerhans Cells)
Cellular localisation: Cell surface and cytoplasmic - Molecular Weight
- 48kDa
- Gene ID
- 50489, 199731
- UniProt
- Q9UJ71
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