Cathepsin D antibody (AA 104-250)
-
- Target See all Cathepsin D (CTSD) Antibodies
- Cathepsin D (CTSD)
-
Binding Specificity
- AA 104-250
-
Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This Cathepsin D antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificity
- Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52kDa preprocathepsin D that is cleaved and glycosylated to form a 48kDa procathepsin D and then further cleaved to produce 34kDa and 14kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment of human Cathepsin D protein (around aa 104-250) (exact sequence is proprietary)
- Clone
- CTSD-3082
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product CTSD Primary Antibody
-
-
- Application Notes
-
Known_Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: K-562, A431 or SK-BR3 cells. Human kidney, liver, lung or breast tissue
- Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
-
- Target
- Cathepsin D (CTSD)
- Alternative Name
- CTSD (CTSD Products)
- Synonyms
- catD antibody, fb93e11 antibody, fj17b09 antibody, wu:fb93e11 antibody, wu:fj17b09 antibody, LOC398557 antibody, Cathd antibody, CatD antibody, LOC100136761 antibody, CTSD antibody, DKFZp469J0315 antibody, DDBDRAFT_0205785 antibody, DDBDRAFT_0215012 antibody, DDB_0205785 antibody, DDB_0215012 antibody, CLN10 antibody, CPSD antibody, CD antibody, cathepsin D antibody, cathepsin D S homeolog antibody, lysosomal aspartic protease antibody, cathepsin D-like antibody, ctsd antibody, LOC398557 antibody, ctsd.S antibody, CatD antibody, LOC5567565 antibody, LOC100136761 antibody, CTSD antibody, Cathd antibody, ctsD antibody, catd antibody, Ctsd antibody, LOC443060 antibody
- Background
-
CatD, Cathepsin D, Ceroid lipofuscinosis neuronal 10, CLN10, CPSD, Epididymis secretory sperm binding protein Li 130P, Lysosomal aspartyl peptidase, Lysosomal aspartyl protease,Cathepsin D (Tumor Marker)
Cellular localisation: Cytoplasmic - Molecular Weight
- 48kDa (Procathepsin D), 34kDa (Cathepsin D), 14kDa (Cathepsin D)
- Gene ID
- 1509, 654447
- UniProt
- P07339
- Pathways
- Peptide Hormone Metabolism
-