DBN1 antibody (AA 150-281)

Catalog No. ABIN6937083

Product Details anti-DBN1 Antibody

Target: DBN1 (Drebrin 1 (DBN1))

Binding Specificity: AA 150-281

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DBN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: Drebrins (developmentally regulated brain proteins) are cytoplasmic proteins that bind F-actin in the brain and are involved in cell migration, extension of neuronal processes and plasticity of dendrites. There are three isoforms: two embryonic types (E1 and E2), and an adult type (A), generated by alternative RNA splicing from a single Drebrin gene. Drebrins are expressed mainly in brain neurons but are also found in skeletal muscle, heart, placenta, pancreas and kidney. Drebrin has been designated as a marker of the dendritic spine. Decreases in Drebrin levels in the brain have been been associated with Alzheimer s disease and Down syndrome.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (aa 150-281) of human DBN1 protein (exact sequence is proprietary)

Clone: DBN1-2879

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: PC3 cells. Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for DBN1

Target: DBN1 (Drebrin 1 (DBN1))

Alternative Name: DBN1 (DBN1 Products)

Synonyms: D0S117E antibody, DBN1 antibody, LOC733967 antibody, drebrin 1 antibody, drebrin 1 S homeolog antibody, DBN1 antibody, Dbn1 antibody, dbn1.S antibody, dbn1 antibody

Background: Developmentally regulated brain protein, Drebrin 1, Drebrin, Drebrin E, Drebrin E2, Drebrin1, DrebrinE,Drebrin 1 (DBN1)
Cellular localisation: Cytoplasmic

Molecular Weight: 120kDa

Gene ID: 1627, 130316

UniProt: Q16643

Pathways: Maintenance of Protein Location