GPN1 antibody

Catalog No. ABIN6937346

This Mouse Monoclonal antibody specifically detects GPN1 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for GPN1 antibody (ABIN6937346)

Target: GPN1 (GPN-Loop GTPase 1 (GPN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GPN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: GPN1-2350

Product Details anti-GPN1 Antibody

Purpose: GPN1 / XAB1 (DNA Repair & Protein Synthesis) Antibody

Specificity: GPN1 is involved in protein synthesis events. It is expressed ubiquitously with highest expression in testis. It binds to the RNA polymerase II- (Poll II) associated proteins RPAP1-3 and to XPA (a protein involved in DNA repair mechanisms), thereby forming an interface with Poll II. Via this interaction, GPN1 is thought to mediate the involvement of Pol II in both protein complex formation and protein chaperone/ scaffolding activities. In addition, GPN1 interacts with components of the integrator and molecular chaperone complexes, further implicating GPN1 in protein assembly. GPN1 contains a cluster of acidic amino acids in its C-terminal region and a series of sequences similar to those found in GTP-binding proteins in its N-terminal region, suggesting that GPN1 has possible GTPase activity.

Cross-Reactivity (Details): Human.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human GPN1 protein

Isotype: IgG1, kappa

Application Details

Application Notes:

Known_Application: ELISA (For coating, order antibody without BSA), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: Pancreas, Testis, Thyroid or Bladder.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for GPN1

Target: GPN1 (GPN-Loop GTPase 1 (GPN1))

Alternative Name: GPN1

Background:

ATP(GTP) binding protein (ATPBD1A), GPN-loop GTPase 1, GPN1, MBD2-interacting protein (MBDin), NTPBP, RNA polymerase II associated protein 4 (RPAP4), XPA-binding protein 1 (XAB1) GTPase

Pancreas, Testis, Thyroid or Bladder.

Molecular Weight: 42kDa

Gene ID: 11321, 18259

UniProt: Q9HCN4