GPN1 antibody

Catalog No. ABIN6939142

Product Details anti-GPN1 Antibody

Target: GPN1 (GPN-Loop GTPase 1 (GPN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GPN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Coating (Coat)

Purification: Purified by Protein A/G

Immunogen: Recombinant full-length human GPN1 protein

Clone: GPN1-2350

Isotype: IgG1 kappa

Application Details

Application Notes:

Positive Control: Pancreas, Testis, Thyroid or Bladder.

Known Application: ELISA (For coating, order antibody without BSA), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for GPN1

Target: GPN1 (GPN-Loop GTPase 1 (GPN1))

Alternative Name: GPN1 (GPN1 Products)

Synonyms: ATPBD1A antibody, MBDIN antibody, NTPBP antibody, RPAP4 antibody, XAB1 antibody, GPN1 antibody, MGC137872 antibody, 2410004J02Rik antibody, AI449615 antibody, Xab1 antibody, GPN-loop GTPase 1 antibody, GPN1 antibody, Gpn1 antibody

Background: GPN1 is involved in protein synthesis events. It is expressed ubiquitously with highest expression in testis. It binds to the RNA polymerase II- (Poll II) associated proteins RPAP1-3 and to XPA (a protein involved in DNA repair mechanisms), thereby forming an interface with Poll II. Via this interaction, GPN1 is thought to mediate the involvement of Pol II in both protein complex formation and protein chaperone/ scaffolding activities. In addition, GPN1 interacts with components of the integrator and molecular chaperone complexes, further implicating GPN1 in protein assembly. GPN1 contains a cluster of acidic amino acids in its C-terminal region and a series of sequences similar to those found in GTP-binding proteins in its N-terminal region, suggesting that GPN1 has possible GTPase activity.

Molecular Weight: 42kDa

Gene ID: 11321