Neuregulin 1 antibody (AA 21-242)

Catalog No. ABIN6938088

The Mouse Monoclonal anti-Neuregulin 1 antibody has been validated for IHC (f). It is suitable to detect Neuregulin 1 in samples from Human.

Quick Overview for Neuregulin 1 antibody (AA 21-242) (ABIN6938088)

Target: Neuregulin 1 (NRG1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neuregulin 1 antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: NRG1-2710

Product Details anti-Neuregulin 1 Antibody

Binding Specificity: AA 21-242

Specificity: Heregulin-1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment of human Neuregulin-1 (NRG1) protein (around aa 21-242) (exact sequence is proprietary)

Isotype: IgG1 kappa

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: A431, MCF-7 or T47D cells. Breast, Bladder or Thyroid Carcinoma.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for Neuregulin 1

Target: Neuregulin 1 (NRG1)

Alternative Name: NRG1

Background: Acetylcholine receptor-inducing activity (ARIA), Breast cancer cell differentiation factor p45, Glial growth factor (GGF2), Heregulin-1, Heregulin, alpha (45kD, ERBB2 p185-activator), HGL, HRG1, HRGA, MST131, Neu Differentiation Factor (NDF), Neuregulin-1, NRG1, Sensory and Motor Neuron-Derived Factor (SMDF),Heregulin-1 / Neuregulin-1 (Breast and Urothelial Marker)
Cellular localisation: Cell Surface and Cytoplasmic (Secreted)

Molecular Weight: 26-71kDa

Gene ID: 3084, 453951, 668810

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation