Ret Proto-Oncogene antibody (AA 702-848)

Catalog No. ABIN6938320

The Mouse Monoclonal anti-Ret Proto-Oncogene antibody (Clone RET-2795) (ABIN6938320) specifically detects Ret Proto-Oncogene in IHC. The antibody is reactive with Human samples.

Quick Overview for Ret Proto-Oncogene antibody (AA 702-848) (ABIN6938320)

Target: Ret Proto-Oncogene (RET)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ret Proto-Oncogene antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: RET-2795

Product Details anti-Ret Proto-Oncogene Antibody

Binding Specificity: AA 702-848

Purpose: RET Proto-oncogene Antibody

Specificity: The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system, in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney.Alterations in RETgene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung's disease.

Cross-Reactivity (Details): Human.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 702-848) of human RET protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Positive_Control: Breast, Prostate or Colon Carcinoma.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Ret Proto-Oncogene

Target: Ret Proto-Oncogene (RET)

Alternative Name: RET

Background:

Cadherin family member 12 (CDHF12), Cadherin related family member 16 (CDHR16), ELKS, HSCR1, Hydroxyaryl protein kinase, MEN2A, MEN2B, MTC1, Multiple endocrine neoplasia and medullary thyroid carcinoma 1, Oncogene RET, Proto-oncogene c-Ret, Proto-oncogene tyrosine-protein kinase receptor ret, PTC, RET, RET ELE1, RET51, RET9

Breast, Prostate or Colon Carcinoma.

Molecular Weight: 150kDa (precursor), 170kDa (Mature)

Gene ID: 5979, 350321

UniProt: P07949

Pathways: RTK Signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation