TAL1 antibody
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- Target See all TAL1 Antibodies
- TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TAL1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Coating (Coat)
- Specificity
- Activation of TAL1 characterizes up to 60 % of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors.
- Cross-Reactivity (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human full-length TAL1 protein
- Clone
- BTL73
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product TAL1 Primary Antibody
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- Application Notes
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Known_Application: ELISA (For coating, order antibody without BSA), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: A549 xenograft.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Preservative
- Azide free
- Storage
- -20 °C,-80 °C
- Storage Comment
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Expiry Date
- 24 months
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- Target
- TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))
- Alternative Name
- TAL1 (TAL1 Products)
- Synonyms
- SCL/tal-1 antibody, Scl antibody, bHLHa17 antibody, tal-1 antibody, SCL antibody, TCL5 antibody, scl antibody, tcl5 antibody, SCL-alpha antibody, SCL-beta antibody, scl/tal1 antibody, zgc:85605 antibody, T cell acute lymphocytic leukemia 1 antibody, TAL bHLH transcription factor 1, erythroid differentiation factor antibody, T-cell acute lymphocytic leukemia 1 S homeolog antibody, T-cell acute lymphocytic leukemia 1 antibody, Tal1 antibody, TAL1 antibody, tal1.S antibody, tal1 antibody
- Background
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BHLHa17, Class A basic helix-loop-helix protein 17, OTTHUMP00000009563, OTTHUMP00000009564, SCL, STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR, Stem cell protein, T cell acute lymphocytic leukemia 1, T cell acute lymphocytic leukemia 1 protein, T cell acute lymphocytic leukemia 1 protein, T cell leukemia/lymphoma 5 protein, T-cell acute lymphocytic leukemia protein 1, T-cell leukemia/lymphoma protein 5, Tal 1 product, TAL 1 protein, TAL bHLH transcription factor 1 erythroid differentiation factor, TAL-1,Tal1
Cellular localisation: Nuclear. - Molecular Weight
- 42kDa
- Gene ID
- 6886, 705618
- UniProt
- P17542
- Pathways
- Stem Cell Maintenance
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