Neuregulin 1 antibody (AA 21-242)

Catalog No. ABIN6939613

This anti-Neuregulin 1 antibody is a Mouse Monoclonal antibody detecting Neuregulin 1 in IHC and StM. Suitable for Human.

Quick Overview for Neuregulin 1 antibody (AA 21-242) (ABIN6939613)

Target: Neuregulin 1 (NRG1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neuregulin 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: NRG1-2710

Product Details anti-Neuregulin 1 Antibody

Binding Specificity: AA 21-242

Purification: Purified by Protein A/G

Immunogen: Recombinant fragment of human Neuregulin-1 (NRG1) protein (around aa 21-242) (exact sequence is proprietary)

Isotype: IgG1 kappa

Application Details

Application Notes:

Positive Control: A431, MCF-7 or T47D cells. Breast, Bladder or Thyroid Carcinoma.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Neuregulin 1

Target: Neuregulin 1 (NRG1)

Alternative Name: NRG1

Background: Heregulin-1 is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Molecular Weight: 26-71kDa

Gene ID: 3084

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation