SOD1 antibody

Catalog No. ABIN6940610

The Mouse Monoclonal anti-SOD1 antibody has been validated for ELISA and Coat. It is suitable to detect SOD1 in samples from Human.

Quick Overview for SOD1 antibody (ABIN6940610)

Target: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SOD1 antibody is un-conjugated

Application: ELISA, Coating (Coat)

Clone: SOD1-2089

Product Details anti-SOD1 Antibody

Purification: Purified by Protein A/G

Immunogen: Recombinant full-length human SOD1 protein

Isotype: IgG2b kappa

Application Details

Application Notes:

Positive Control: HeLa or Jurkat cells. Breast or Ovarian carcinoma.

Known Application: ELISA (For coating use Ab at 1-5 μg/mL, order Ab without BSA) Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for SOD1

Target: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Alternative Name: SOD1

Background: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer's disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

Molecular Weight: 23kDa

Gene ID: 6647

UniProt: P00441

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis