Tyrosinase-Related Protein 1 antibody

Catalog No. ABIN6940839

This Mouse Monoclonal antibody specifically detects Tyrosinase-Related Protein 1 in IF, FACS, WB and IHC (fro). It exhibits reactivity toward Human and Mouse.

Quick Overview for Tyrosinase-Related Protein 1 antibody (ABIN6940839)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Tyrosinase-Related Protein 1 antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: TA99-TYRP1-807

Product Details anti-Tyrosinase-Related Protein 1 Antibody

Specificity: It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Purification: Purified by Protein A/G

Immunogen: SK-MEL-23 cells (TA99), Recombinant full-length human TYRP1 protein (TYRP1/807)

Isotype: IgG2a kappa

Application Details

Application Notes:

Positive Control: SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells. Melanoma.

Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (0.5-1 μg/mL), Immunohistochemistry (Frozen only) (0.5-1 μg/mL for 30 minutes at RT)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Alternative Name: TYRP1

Molecular Weight: 75kDa

Gene ID: 7306

UniProt: P17643