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Recombinant CD14 antibody (AA 25-148)

This anti-CD14 antibody is a Mouse Monoclonal antibody detecting CD14 in IHC, ISt and StM. Suitable for Human.
Catalog No. ABIN6941088

Quick Overview for Recombinant CD14 antibody (AA 25-148) (ABIN6941088)

Target

See all CD14 Antibodies
CD14

Antibody Type

Recombinant Antibody

Reactivity

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Human

Host

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Mouse

Clonality

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Monoclonal

Conjugate

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This CD14 antibody is un-conjugated

Application

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Immunohistochemistry (IHC), Immunostaining (ISt), Staining Methods (StM)

Clone

RLPSR-2408
  • Binding Specificity

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    AA 25-148

    Specificity

    Recognizes a protein of 55 kDa, identified as CD14 (also known lipopolysaccharide receptor). CD14 is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation.

    Purification

    Purified by Protein A/G

    Immunogen

    Recombinant fragment of human CD14 protein (around aa 25-148) (exact sequence is proprietary)

    Isotype

    IgG1 kappa
  • Application Notes

    Positive Control: A549, THP-1 cells and human monocytes. Lymph nodes and tonsils.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Restrictions

    For Research Use only
  • Concentration

    200 μg/mL

    Buffer

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-80 °C

    Storage Comment

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    Expiry Date

    24 months
  • Target

    CD14

    Alternative Name

    CD14

    Molecular Weight

    55kDa

    Gene ID

    929

    UniProt

    P08571

    Pathways

    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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