VEGFR2/CD309 antibody

Catalog No. ABIN6941304

The Rat Monoclonal anti-VEGFR2/CD309 antibody has been validated for WB, Neut and Bind. It is suitable to detect VEGFR2/CD309 in samples from Mouse.

Quick Overview for VEGFR2/CD309 antibody (ABIN6941304)

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This VEGFR2/CD309 antibody is un-conjugated

Application: Western Blotting (WB), Neutralization (Neut), Binding Studies (Bind)

Clone: DC101

Product Details anti-VEGFR2/CD309 Antibody

Specificity: This MAb is specific to Mouse VEGFR2/FLK-1/CD309 and does not cross-react with FLK-2. VEGFR2 is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Endothelial cells, embryonic tissues, and megakaryocytes mainly express VEGFR2. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.

Purification: Purified by Protein A/G

Immunogen: Recombinant full-length Mouse VEGFR2 protein

Isotype: IgG1 kappa

Application Details

Application Notes:

Positive Control: Mouse epidermoid, renal cell carcinoma, pancreatic or glioblastoma cells.

Known Application: Western Blot (Non-reducing) (2-5 μg/mL), Blocks Binding of VEGF to VEGF-R2 (Order Ab without BSA & Azide), Inhibits VEGF-induced Signaling (Order Ab without BSA & Azide), Blocks Tumor Growth in mice (Order Ab without BSA & Azide), Neutralizing, Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for VEGFR2/CD309

Target: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Alternative Name: Kdr

Molecular Weight: 180-190kDa

Gene ID: 16542, 35918

Pathways: RTK Signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling