ACTN2 antibody (AA 1-150)

Catalog No. ABIN6942045

This Rabbit Monoclonal antibody specifically detects ACTN2 in WB, IP and IHC (p). It exhibits reactivity toward Human.

Quick Overview for ACTN2 antibody (AA 1-150) (ABIN6942045)

Target: ACTN2 (Actinin, alpha 2 (ACTN2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ACTN2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 7G3

Product Details anti-ACTN2 Antibody

Binding Specificity: AA 1-150

Purpose: ACTN2 (7G3) Monoclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant protein within human ACTN2 aa 1-150.

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), IHC-P(1:200-400), IP(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ACTN2

Target: ACTN2 (Actinin, alpha 2 (ACTN2))

Alternative Name: ACTN2

Background:

Synonyms: Alpha-actinin-2, ACTN2, Sarcomeric Alpha Actinin, Alpha-actinin skeletal muscle isoform 2, F-actin cross-linking protein, CMH23, CMD1AA

Background: ACTN2 is a member of the alpha-actin binding protein gene family. ACTN2 is primarily expressed in skeletal muscle and functions as a structural component of the sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants, the reference genome represents the coding allele. The non-functional allele of this gene is associated with elite athlete status. ACTN2 is an F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. ACTN2 is a bundling protein.

Gene ID: 88

UniProt: P35609

Pathways: Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity