Angiopoietin 2 antibody (AA 200-350)

Catalog No. ABIN6942114

This Rabbit Monoclonal antibody specifically detects Angiopoietin 2 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Angiopoietin 2 antibody (AA 200-350) (ABIN6942114)

Target: Angiopoietin 2 (ANGPT2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Angiopoietin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4G2

Product Details anti-Angiopoietin 2 Antibody

Binding Specificity: AA 200-350

Purpose: Angiopoietin 2 (4G2) Monoclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Human Angiopoietin 2 aa 200-350

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), IHC-P(1:200-400)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Angiopoietin 2

Target: Angiopoietin 2 (ANGPT2)

Alternative Name: ANGPT2

Background:

Synonyms: Angiopoietin-2, ANG-2, ANGPT2.

Background: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Gene ID: 285

UniProt: O15123

Pathways: RTK Signaling