ATG16L1 antibody (AA 1-150)

Catalog No. ABIN6942170

The Rabbit Monoclonal anti-ATG16L1 antibody (Clone 1B6) (ABIN6942170) specifically detects ATG16L1 in WB and IF (cc). The antibody is reactive with Human samples.

Quick Overview for ATG16L1 antibody (AA 1-150) (ABIN6942170)

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ATG16L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 1B6

Product Details anti-ATG16L1 Antibody

Binding Specificity: AA 1-150

Purpose: ATG16L1 (1B6) Monoclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant protein within human ATG16L1 aa 1-150

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ATG16L1

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Alternative Name: ATG16L1

Background:

Synonyms: Autophagy-related protein 16-1, APG16-like 1, ATG16L1, APG16L.

Background: Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Plays a role in regulating morphology and function of Paneth cell.

Gene ID: 55054

UniProt: Q676U5

Pathways: Autophagy