Caspase 2 antibody (AA 150-350)

Catalog No. ABIN6942345

This Rabbit Monoclonal antibody specifically detects Caspase 2 in WB, FACS, IHC (p), IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for Caspase 2 antibody (AA 150-350) (ABIN6942345)

Target: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Caspase 2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Clone: 2B1

Product Details anti-Caspase 2 Antibody

Binding Specificity: AA 150-350

Purpose: Caspase 2 (2B1) Monoclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant human Caspase-2 between 150 to 350 amino acids

Isotype: IgG

Application Details

Application Notes: WB(1:500-2000), FCM(1:100-500), IHC-P(1:200-500), IF(IHC-P)(1:100-500), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Caspase 2

Target: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Alternative Name: CASP2

Background:

Synonyms: Caspase-2, Neural precursor cell expressed developmentally down-regulated protein 2, Protease ICH-1, CASP-2, NEDD-2, Caspase-2 subunit p18

Background: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress.

Gene ID: 835

UniProt: P42575

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway