EGFRviii antibody (AA 321-520)

Catalog No. ABIN6943225

Product Details anti-EGFRviii Antibody

Target: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Binding Specificity: AA 321-520

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EGFRviii antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EGFRvIII

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for EGFRviii

Target: EGFRviii (EGFRv3) (EGFR vIII (EGFRv3))

Alternative Name: EGFRvIII (EGFRv3 Products)

Background:

Synonyms: GFRvIII, Epidermal growth factor receptor variant type _, epidermal growth factor receptor isoform a variant.

Background: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Gene ID: 1956

UniProt: P00533