EXOSC4 antibody (AA 51-150) (HRP)

Catalog No. ABIN6943358

Product Details anti-EXOSC4 Antibody (HRP)

Target: EXOSC4 (Exosome Component 4 (EXOSC4))

Binding Specificity: AA 51-150

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC4 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EXOSC4

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for EXOSC4

Target: EXOSC4 (Exosome Component 4 (EXOSC4))

Alternative Name: EXOSC4 (EXOSC4 Products)

Synonyms: EXOSC4 antibody, zgc:73175 antibody, RRP41 antibody, RRP41A antibody, Rrp41p antibody, SKI6 antibody, Ski6p antibody, hRrp41p antibody, p12A antibody, 1110039I09Rik antibody, 1500001N04Rik antibody, Rrp41 antibody, exosome component 4 antibody, exosome component 4 S homeolog antibody, exosc4 antibody, EXOSC4 antibody, CC1G_03561 antibody, exosc4.S antibody, Exosc4 antibody

Background:

Synonyms: EXOSC 4, Exosome complex component RRP41, Exosome complex exonuclease RRP41, Exosome component 4, Exosome component Rrp41, FLJ20591, hRrp41p, p12A, EXOS4_HUMAN, Ribosomal RNA processing protein 41, RRP 41, RRP41, RRP41A, Rrp41p, SKI 6, SKI6, Ski6p.

Background: The exosome is a multisubunit complex composed of several highly conserved subunits, some of which are 3 to 5 exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3 region. EXOSC4 (exosome component 4), also known as SKI6, RRP41 or p12A, is a 245 amino acid protein that localizes to both the nucleus and the cytoplasm and shares 96 % sequence identity with its mouse counterpart. Functioning as a component of the exosome complex, EXOSC4 exhibits 3'-5' exonuclease activity and is required for the 3'-processing of 7S pre-RNA to mature 5.8S rRNA. The gene encoding EXOSC4 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

Gene ID: 54512

UniProt: Q9NPD3