Growth Hormone Receptor antibody (AA 500-630)

Catalog No. ABIN6943577

The Rabbit Monoclonal anti-Growth Hormone Receptor antibody (Clone 3C5) (ABIN6943577) specifically detects Growth Hormone Receptor in WB, FACS, IF (cc), IF (p) and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Growth Hormone Receptor antibody (AA 500-630) (ABIN6943577)

Target: Growth Hormone Receptor (GHR)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Growth Hormone Receptor antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 3C5

Product Details anti-Growth Hormone Receptor Antibody

Binding Specificity: AA 500-630

Purpose: Growth hormone receptor Recombinant Antibody

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat

Purification: Purified by Protein A.

Immunogen: Synthetic peptide within human Growth hormone receptor aa 500-630

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), FCM(1:20-100), IHC-P(1:200-400), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Growth Hormone Receptor

Target: Growth Hormone Receptor (GHR)

Alternative Name: Growth hormone receptor

Background:

Synonyms: Growth hormone receptor, Somatotropin receptor, Growth hormone-binding protein, Serum-binding protein, GH receptor, GH-binding protein, GHBP, GHR.

Background: GHR is a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. It is a receptor for pituitary gland growth hormone involved in regulating postnatal body growth. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene

Gene ID: 2690

UniProt: P10912

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus