INSRR antibody

Catalog No. ABIN6943804

The Rabbit Monoclonal anti-INSRR antibody is suitable to detect INSRR in samples from Human, Mouse and Rat. It has been validated for WB and IHC (p).

Quick Overview for INSRR antibody (ABIN6943804)

Target: INSRR (Insulin Receptor-Related Receptor (INSRR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This INSRR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 8A1

Product Details anti-INSRR Antibody

Purpose: Insulin Receptor R (8A1) Monoclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: N terminal Human Insulin Receptor R

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), IHC-P(1:200-400)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for INSRR

Target: INSRR (Insulin Receptor-Related Receptor (INSRR))

Alternative Name: INSRR

Background:

Synonyms: Insulin receptor-related protein, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain, IRR, INSRR

Background: The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular beta subunit and an extracellular alpha subunit, which is disulfide- linked to a transmembrane segment. Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH . Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

Gene ID: 3645

UniProt: P14616

Pathways: RTK Signaling