MC1 Receptor antibody (AA 181-280) (Biotin)

Catalog No. ABIN6944036

This anti-MC1 Receptor antibody is a Rabbit Polyclonal antibody detecting MC1 Receptor in ELISA, WB, IHC (p) and IHC (fro). Suitable for Human.

Quick Overview for MC1 Receptor antibody (AA 181-280) (Biotin) (ABIN6944036)

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MC1 Receptor antibody is conjugated to Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-MC1 Receptor Antibody (Biotin)

Binding Specificity: AA 181-280

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MC1 Receptor

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for MC1 Receptor

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Alternative Name: MC1 Receptor

Background:

Synonyms: MC1 Receptor, CMM5, MC1-R, MC-1R, MC1R, Melanocortin 1 receptor, Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor), Melanocortin receptor 1, Melanocyte-stimulating hormone receptor, Melanotropin receptor, MSH-R, MSHR, MSHR_HUMAN, SHEP2.

Background: This intronless gene encodes the receptor protein for melanocyte -stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Gene ID: 4157

UniProt: Q01727

Pathways: cAMP Metabolic Process, Feeding Behaviour