Recombinant MLKL antibody (pSer345)

Catalog No. ABIN6944093

The Rabbit Monoclonal anti-MLKL antibody (ABIN6944093) specifically detects MLKL in WB, IF and ICC. The antibody is reactive with Human samples.

Quick Overview for Recombinant MLKL antibody (pSer345) (ABIN6944093)

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MLKL antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-MLKL Antibody

Binding Specificity: pSer345

Purpose: phospho-MLKL (Ser345) Recombinant Antibody

Cross-Reactivity: Mouse

Purification: Purified by Protein A.

Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL

Isotype: IgG

Application Details

Application Notes: WB(1:500-2000), ICC/IF(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for MLKL

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Alternative Name: MLKL

Background:

Synonyms: Phospho-MLKL (S345), pMLKL Ser345, Mixed lineage kinase domain-like protein, Mlkl

Background: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Gene ID: 74568

UniProt: Q9D2Y4