Recombinant MLKL antibody (C-Term)

Catalog No. ABIN6944094

This Rabbit Monoclonal antibody specifically detects MLKL in WB. It exhibits reactivity toward Human.

Quick Overview for Recombinant MLKL antibody (C-Term) (ABIN6944094)

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MLKL antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MLKL Antibody

Binding Specificity: C-Term

Purpose: MLKL Recombinant Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Human MLKL between 350 to C-terminus

Isotype: IgG

Application Details

Application Notes: WB(WB(1:500-2000))

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for MLKL

Target: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Alternative Name: MLKL

Background:

Synonyms: Mixed lineage kinase domain-like protein, hMLKL, MLKL

Background: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).

Gene ID: 197259

UniProt: Q8NB16