Nicastrin antibody

Catalog No. ABIN6944227

The Rabbit Monoclonal anti-Nicastrin antibody is suitable to detect Nicastrin in samples from Human. It has been validated for WB.

Quick Overview for Nicastrin antibody (ABIN6944227)

Target: Nicastrin (NCSTN)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Nicastrin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 3F10

Product Details anti-Nicastrin Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Synthetic peptide within Human Nicastrin aa 650-750 (C terminal).

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Nicastrin

Target: Nicastrin (NCSTN)

Alternative Name: NCSTN

Background:

Synonyms: Nicastrin, NCSTN, KIAA0253, ATAG1874

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.

Gene ID: 23385

UniProt: Q92542

Pathways: Notch Signaling, Neurotrophin Signaling Pathway