ORC2 antibody

Catalog No. ABIN6944371

The Mouse Monoclonal anti-ORC2 antibody is suitable to detect ORC2 in samples from Human. It has been validated for WB and IF (cc).

Quick Overview for ORC2 antibody (ABIN6944371)

Target: ORC2 (Origin Recognition Complex Subunit 2 (ORC2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ORC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 5C3

Product Details anti-ORC2 Antibody

Cross-Reactivity: Human

Purification: Protein G purified monoclonal antibody in PBS containing 0.05% azide.

Immunogen: Monoclonal antibody raised in mouse against human ORC2, using two recombinant proteins containing the N-terminal and C-terminal part of the protein, respectively

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.6 μg/μL

Buffer: PBS with 0.05 % sodium azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ORC2

Target: ORC2 (Origin Recognition Complex Subunit 2 (ORC2))

Alternative Name: ORC2

Background:

Synonyms: ORC2L, Origin recognition complex subunit 2, ORC2

Background: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.

Gene ID: 4999

UniProt: Q13416